In the previous episode, Alice (Milla Jovovich) rescued her frozen companions, but they were killed by mercenaries who rushed to leave. The T-virus makes the Red Queen (Megan Charpentier)'s program go wrong, and she becomes brutal and bloodthirsty and wants to kill the last of mankind and destroy the earth. The only person who can stop the Red Queen is Alice. At this moment, Alice, who had lost her ability, was imprisoned by the Umbrella Company in a secret base on the seabed. Wesker (Shawn Roberts) invades Umbrella's systems through a virus. He releases Alice and tells her that she is mankind's last hope, and that in order to save mankind, they must bury the hatchet and fight together against a more powerful enemy. Alice meets Aida Wang (played by Li Bingbing), a former employee of the Umbrella Company. The two fought bravely to kill enemies along the way and forged a deep friendship. At the same time, Alice's old comrades also formed a small team to break through from the outside to the inside. Umbrella Company built realistic simulated cities on the seabed and used human clones as experimental subjects for the T-virus...